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Wednesday, May 20, 2020 | History

4 edition of Hair analysis of nicotine and cotinine found in the catalog.

Hair analysis of nicotine and cotinine

Hair analysis of nicotine and cotinine

a biological marker for fetal exposure to cigarette smoke.

  • 290 Want to read
  • 19 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 1995.

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL17894965M
ISBN 100612076334
OCLC/WorldCa46511315

Nicotine or Cotinine Test Specimen Type: Urine or Hair Your body breaks down nicotine into many chemicals, including cotinine, which can also be detected in certain tests. Cotinine is found in your body if you had nicotine and it stays in the body longer than nicotine itself. Nicotine is a highly addictive substance that is [ ] View Details. However, it is not reliable in detecting immediate nicotine use. Hair follicles would usually take a few weeks to grow and that’s the best time to check nicotine in the hair follicles. (11, 13) Nicotine Drug Test #1: Blood test for nicotine. Photo 4: A blood sample is drawn from the patient’s upper arm. Picture Source: vapingcom.

Guidelines for Interpreting Cotinine Levels: United States The following guidelines are based largely on the work of Neal Benowitz, These numbers were derived from serum cotinine values as measured by HPLC/MS. Note that optimal cut‐points differ by race/ethnicity and g: Hair analysis.   Florescu A, Ferrence R, Einarson TR, Selby P, Kramer M, Woodruf S, et al. Reference values for hair cotinine as a biomarker of active and passive smoking in women of reproductive age, pregnant women, children and neonates: systematic review and meta-analysis. Therapeutic Drug Monitor. ;– Google Scholar.

Analysis of aternal hair nicotine captures a longer range of SHS exposure than urine or serum cotinine and expired CO and offers a more valid measure of SHS exposure than cotinine analysis from. We measured nicotine and cotinine levels in blood and urine from 31 forensic autopsy cases. Initially, we developed a sensitive and reproducible gas chromatographic method with a minimum limit of.


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Hair analysis of nicotine and cotinine Download PDF EPUB FB2

Nicotine and cotinine in human hair were quantified by using deuterated analytes as internal standards. The quantification limits were 8 µg/L for nicotine and µg/L for cotinine.

The proposed method was applied to measure the concentrations of nicotine and cotinine in hair of smokers and non‐smokers to evaluate their self‐reported smoking and exposure to environmental tobacco by: As suggested by several authors, analysis of nicotine and cotinine in human hair provide information on nicotine intake or exposure to environmental tobacco smoke over a long period of time, in contrast to serum or urine testing [].

Furthermore, hair samples are Cited by: Analysis of nicotine and cotinine in hair by on-line in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry as biomarkers of exposure to tobacco smoke - by: A 20 microL aliquot of redissolved solution was subjected to analysis.

Nicotine and cotinine in human hair were quantified by using deuterated analytes as internal standards. The quantification limits were 8 microg/L for nicotine and microg/L for cotinine.

The analysis of nicotine in hair using gas chromatography with mass spectrometric detection was first described in the seminal work by Zahlsen and Nilsen (); the use of the method in the. Analysis of nicotine and cotinine in hair by on-line in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry as biomarkers of exposure to tobacco smoke.

Inukai T(1), Kaji S(1), Kataoka H(2). Author information: (1)School of Pharmacy, Shujitsu University, Nishigawara, Okayamaby: The purpose of this study was to determine if hair nicotine and cotinine levels reflect relative exposure to environmental tobacco smoke (ETS) in subjects who worked in the hospitality industry, where public smoking was permitted.

Hair samples from 26 subjects were analyzed by gas chromatograph/mass spectrometry techniques for nicotine and. ass spectrometry techniques for nicotine and cotinine.

An exposure gradient was shown for nicotine but not cotinine. Among nonsmokers, those working in bars where there are no public smoking restrictions had the highest hair nicotine levels, which were close to levels found in smokers.

Nicotine measured in hair is useful as a biological marker for exposure to ETS from multiple sources. Bar. Analysis for nicotine and cotinine in hair to determine cigarette smoker status. Haley NJ, Hoffmann D. Noninvasive validation of cigarette smoking behavior is necessary for large population studies, especially with adolescents, where peer pressures can compromise by: Thus, hair nicotine provides an extended exposure assessment when compared with blood, urinary, or salivary concentrations of nicotine or cotinine.

Hair nicotine as a SHS exposure assessment has added advantages for the study of young children because hair samples are easy and noninvasive to obtain, store, and transport, and parental consent is easier to obtain than other by:   We analyzed scalp hair from smokers and controls, to see whether hair could provide reliable samples for determining nicotine uptake.

The amounts of nicotine and cotinine we detected in these samples correlated with individual smoking habits and by: The research indicates the usefulness of hair analysis to assess exposure to nicotine and cotinine.

The pattern of results indicates a more effective absorption of nicotine from e-cigarette vapour, when compared to nicotine contained within tobacco : L. Cashman, J.

Nutt. Cotinine may even intercalate (get inserted) into hair; Cotinine serves as a better indicator for nicotine levels than measuring nicotine directly due to its longer half-life and greater stability. Furthermore, the only source of cotinine is the degradation of nicotine; thus, further validating cotinine testing; The Nicotine (or Cotinine) Hair.

In this pilot study, we examined the validity and usefulness of hair nicotine–cotinine evaluation as a biomarker of monitoring exposure to tobacco. Head hair samples were collected from 22 infants (smoking) and analyzed by liquid Cited by:   Analytical parameters for the performed nicotine and cotinine analysis using head hair samples +1 Hair nicotine and cotinine concentrations (ng/mg) among adults according to smoking.

Analysis of the hair of a perinate recovered from a rock shelter in Northern Chile and dated ca. 2, yrs BP showed the presence of nicotine and its main metabolic product, cotinine. Our findings indicate that hair nicotine is a useful biomarker for the assessment of long-term tobacco smoke exposure.

Our study also provides cutoff value of hair nicotine as well as salivary cotinine for distinguishing AS from PS and by: Cotinine, the active metabolite of nicotine, is evaluated in smoking cessation programs and is used as a key indicator of risk in life insurance testing.

Urine and salivary cotinine can be evaluated using a series of ELISA test kits. The first study to compare urine cotinine levels to hair nicotine levels 1 looked at hair nicotine and urine cotinine as biomarkers of ETS in a population of 94 children aged 1–3 years from Norway.

They reported that nicotine in children's hair correlated more closely with parental smoking history (r =p cotinine in urine (r =p Cited by: nine per mg creatinine for the purpose of analysis.

All main analyses for hair nicotine measure of exposure were re-run using the sample of children who had provided both urine cotinine and hair nicotine (n=) to assess the exclusion/ inclusion effect of children who provided hair.

Cotinine may also be measured in saliva and in hair, although hair testing is primarily used in a research setting, such as a study of non-smokers exposure to tobacco smoke. A blood or urine nicotine test may be ordered by itself or along with cotinine if a healthcare practitioner suspects that someone is experiencing a nicotine overdose.The mean values of nicotine and cotinine in the hair in each group was calculated.

To examine the usefulness of the HPLC/UV method, present methods and results were compared with major studies. In addition, the correlation of sum total nicotine and cotinine in hair and number of cigarettes smoked per day were checked for the smoker group.Haley NJ, Hoffmann D.

Analysis for nicotine and cotinine in hair to determine cigarette smoker status. Clin Chem. Oct; 31 (10)– Kintz P, Kieffer I, Messer J, Mangin P. Nicotine analysis in neonates' hair for measuring gestational exposure to tobacco.

J Forensic Sci. Jan; 38 (1)–Cited by: